Colorimetric and titrimetric determination of cefotaxime sodium in bulk powder and pharmaceutical formulations

Two procedures were adopted for determination of cefotaxime sodium in its pure and dosage forms. In the first procedure cefotaxime sodium was treated with sodium nitrite [1%, 1 ml] in the presence of hydrochloric acid [0.5%, 1 ml]. The developed red color exhibits an absorption maximum at 505 nm. Linear correlations were obtained between the absorbance of nitroso product and drug concentration over the range 80-240 mug ml-1. Upon rendered the medium alkaline with sodium hydroxide solution [1%, 1 ml], the red color was changed into violet color. The produced violet color has an absorption maximum at 563 nm and linearity in the range 80-160 mug ml-1 of cefotaxime sodium. In the second method, the utility of N-bromosuccinimide [NBS] and N-chlorosuccinimide [NCS] in estimation of cefotaxime sodium has been investigated. The study of reaction conditions revealed that, l mole of cefotaxime sodium reacts with 3 moles of NBS or NCS. The optimum time for complete the reaction was found to be 20 minutes. The method permits the determination of 1.5913 mg of cefotaxime sodium

Utilization of N-bromosuccinimide and N-chlorosuccinimide for colorimetric determination of azapropazone in bulk powder and capsules

Two simple and accurate procedures are described for colorimetric determination of anti-inflammatory drug, azapropazone. The procedures involve the use of N-bromosuccinimide [NBS] and N-chlorosuccinimide [NCS] for determining azapropazone in bulk powder and pharmaceutical formulation. The optimum reactions conditions were studied. In the first procedure, azapropazone was dissolved in ethanol, treated with NBS solution [1%, 5 ml] and sulfuric acid [5 ml]. The red color produced exhibits and absorption maximum at 488 nm. Different concentrations ranging from 80 to 320 muml-1 of azapropazone were measured. In the second procedure, the yellow color developed upon the treatment of azapropazone with NCS solution [0.5%, 2 ml] in different media exhibits an absorption maximum at 451 nm. Linearity of the absorbance of yellow color versus the concentration of azapropazone was verified in the ranges 5-50, 20-100 mug m1-1 for aqueous, acidic and basic media, respectively. Both procedures described here were applied for the determination of azapropazone in the pure state and in prolixan capsules. The procedures proposed here are precise and reproducible